MovDisordV3, Main, Exploration, bibRecord, 003171

Substantia nigra hyperechogenicity as a marker of predisposition and slower progression in Parkinson's disease

Identifieur interne : 003171 ( Main/Exploration ); précédent : 003170; suivant : 003172

Substantia nigra hyperechogenicity as a marker of predisposition and slower progression in Parkinson's disease

Auteurs : Katherine J. Schweitzer [Allemagne] ; Rüdiger Hilker [Allemagne] ; Uwe Walter [Allemagne] ; Lothar Burghaus [Allemagne] ; Daniela Berg [Allemagne]

Source :

Movement Disorders [ 0885-3185 ] ; 2006-01.

RBID : ISTEX:738D9B8A40CDE715620F856108F49C34D55105C4

Descripteurs français

Pascal (Inist)
- Exploration ultrason, Locus niger, Parkinson maladie, Système nerveux pathologie.

English descriptors

KwdEn :
- Adult, Aged, Disease Progression, Echoencephalography, Female, Humans, Locus niger, Male, Mathematical Computing, Middle Aged, Nervous system diseases, Parkinson Disease (ultrasonography), Parkinson disease, Parkinson's disease, Positron-Emission Tomography, Prognosis, SN hyperechogenicity, Sensitivity and Specificity, Sonography, Substantia Nigra (ultrasonography), disease progression, predisposition, transcranial sonography (TCS).
MESH :
- ultrasonography : Parkinson Disease, Substantia Nigra.
- Adult, Aged, Disease Progression, Echoencephalography, Female, Humans, Male, Mathematical Computing, Middle Aged, Positron-Emission Tomography, Prognosis, Sensitivity and Specificity.

Abstract

Increased echogenic size (hyperechogenicity) of the substantia nigra (SN) is a characteristic transcranial sonography finding in patients with Parkinson's disease (PD). The SN echogenic size does not change in the course of the disease. In order to see whether this stable ultrasound marker may give any implications for the rate of PD progression, we sonographically investigated 16 PD patients in whom the rate of progression had been determined by serial 18‐fluorodopa positron emission tomography over a follow‐up period of 65.7 ± 26.7 months. We found a significant negative correlation between the right‐to‐left averaged SN echogenic size and the rate of disease progression in the caudate nucleus and in the putamen. There was a tendency towards a younger age at symptom onset in patients with SN hyperechogenicity. It may therefore be hypothesized that a differing influence of factors determining SN echogenicity early in life and impairing forces occurring later in life may account for different pathogenetic subgroups of idiopathic PD. © 2005 Movement Disorder Society

Url:

https://api.istex.fr/document/738D9B8A40CDE715620F856108F49C34D55105C4/fulltext/pdf

DOI: 10.1002/mds.20669

Affiliations:

Le document en format XML

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Movement Disorders (revue)

Substantia nigra hyperechogenicity as a marker of predisposition and slower progression in Parkinson's disease

Substantia nigra hyperechogenicity as a marker of predisposition and slower progression in Parkinson's disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
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